Para coccidioidomycosis is very dangerous disease. It was founded in the brazil and the American Country .It was attacked by children’s as well as adults .The adults of the age 20 to 25 are the most affected. This disease was spread due to a fungus call precocious .
It was founded in the people with work in the areas where it was present . It attacked the skin and caused the spot formation. The pain is very heavies caused as this caught. Its spores are attacked on the skin and entered the blood. There they live and cause the fertilization. This increases in number and the egg becomes large and the sport forms.
This is also known as South American blastomycosis. Different fungus causes blastomycosis which is caused by PCM (Para coccidioidomycosis).
Occurrence of Para coccidioidomycosis
It is mycosis of lungs skin mucus and membrane .It also damage the lymphatic systems and the organs which belong to the lymphatic systems .It was spreads due to fungus It was founded in the brazil and the pain in the skin and the abdomen was major.
The cure was very difficult but when the medicine is given to the patients as a medicine used for its prevention.
History of Para coccidioidomycosis
There were different scientists to study the disease and its symptoms. They also study the transformation of disease. A list of scientists is given below.
Its first case was reported in 1892 Its first case was discovered in the nineteenth was the time of the year of 1892 Many scientists work on this disease .
Of some names are as the said as hospital the clinicals.It was a medical center was developed by Jose de san .This was to discovered the infection of the disease and fined the germs of their disease finned by the patients.They constructed a laboratory and cultured the fungus .
The make examine under the microscope fined that this was Para coccidioidomycosis.It was first discovered in brazil .It was also reported in twenty century .
This disease is very dangerous to organisms specially for humans.
Italo-Brazilian Parasitologist and Florian Paulo de Almeida in (1898-1977) Brazilian pathologist the study was done in brazil and this disease was discovered in the tenths century It was found in other countries such as.
- North American blastomycosis.
- List of cutaneous conditions.
Symptoms of Para coccidioidomycosis
This disease is caused by infection .It is mostly occur in men who are working in outdoor places .It is caused by fungus called Paracoccidioidomycosis .
The common symptoms are included as the spot on skin and lungs .This is very dangerous disease as of mouth and lunges .
Age wise its symptoms are different. As adults the symptoms are on spots on the throat and mouth. The looseness of the voice included it.
In children the symptoms included as swollen the lymph node and cause the severe pain .It can occur in healthy people and caused by paracoccidioidomicosis.
The immune system of the person is on the weekend gradually.
A Visitor Jack had when he visited Brazil and he had caught the symptoms including a cough . pain in throat , spots on skin ,weight lose , weaker , quickly sick day by day .
Today the scientists find the following symptoms. The symptoms of Paracoccidioidomycosis are very dangerous and terrifying to look at. These included as:
- Productive cough
- The lesions of the mouth and throat
- The rapidly weight loss
- The swollen of the lymph nodes
- The fast fever
- Skin Ulcers
- The fatigue
The other common symptoms included as:
1) Breathe shortness.
2) Productive cough.
4) Weight loss.
7) Visually lesions are present on the face.
8) Skin ulcers.
10) Pain in the abdominal organ involvement.
Enlarged liver and spleen
Pain in abdominal organ involvement
Pattern of the Para coccidioidomycosis
The pattern of the disease is
In this pattern the infection wea attacked on to the face and mouth .It was also attacked on the nasal cavity and the pathway of nasal cavity .The yeast was present in this process .It attacked as in the granular forms .
In this process the fungus attacked on the cervical parts and on the axillary parts. The nodes become large and large.
In this method the liver , spleen and the abdominal nodes become large and cause pain in the nodes.
Causes of Para coccidioidomycosis
There are the following causes of PCM (Paracoccidioidomycosis).
- It is the Infection occurs in the lungs.
- It is also spread to the skin.
- It is also found in the Mucous membrane.
- It is also present in the other parts of the body.
- It is also found in Lymph nodes.
- Paracoccidioidomycosis most in men aged 20 to 50.
- It is as Yeast a pilot’s wheel like appearance.
- It is like Paracoccidioidomycosis infects the child in Brazil.
- It is fertile.
Mechanism of Para coccidioidomycosis
Para coccidioidomycosis is caused by the fungus. This fungus infects the respiratory tract of the host. The throat of the patient was infected seriously. PCM involves in the mucous membrane, bones, lungs, systemic mycosis causes disease in immunocompetent hosts.
This increases the fungus aggressiveness. It rarely caused disease in fertile age women. Primary infection is sometimes called as asymptomatic valley fever. Also occurs with high prostrating fever.
Young people appear in the form of akin. Painful lesions start in the lips pulmonary involvement start as lobar pneumonia. On the ninth day, the patient is fertile and coughs without remission. Other organs, bones, arteries, spleen and meninges are involved but these are very rare.
Chronic Para coccidioidomycosis develops pulmonary fibrosis. PCM shows characteristics of wheel shaped yeast.
Diagnosis of Para coccidioidomycosis
The diagnosis of this disease is detected through the patient history and live style checking .
The history tell the patients lively hood and the symptoms that cause by this disease as described above .When a fungus is sometime detected on the body of the patients the disease started .By checking it under microscope we can understand the symptoms and the disease of its The fungus can be culture into the laboratory and the fungus visualised and the examiner under the microscope.
The diagnosis can be easily done by cutting a Piece of infected areas of patients and examining them under a microscope .It is also cultured in laboratories and when it increases in number the microscopic examination can occur to scientists .
A health care can be provided to symptoms to health people and test to the sick people required .The generally test is x-ray test .Under the examination the x-ray test is helpful to diagnose it .
Aften health care also provided biopsy to check this disease symptoms .In this the infected person can be took in to laboratory .A part of it body cut and examine it under microscope .It is cultured in the lab and also increase in the number .After this the sample put on the stage of microscope and examine it under low and high magnification .Some time blood sample is more helpful to testing the paracoccidioidomycosis .
Diagnosis is given below.
- Biopsy of infected tissue.
- Shows characteristics of wheel-shaped yeast.
- Superficial scrapings.
- In the majority cases radiography of the chest reveals interstitial infiltrates.
Epidemiology of Para coccidioidomycosis
PCM is prevalent in Brazil, Argentina, Colombia and Venezuela and also in rural areas. The patient men aged 30 to 50 years old.
How can we get paracoccidioidomycosis?
It usually occurs in those people who live in rural areas and work in the outdoors . The fungus can be attacked in the age of adult more but the children are mostly infected .Their skin and face are spotted as granules . The fungus entered into the mouth of a person and cause infection .
When this fungus present in the air , by breathing it can be entered .So the symptoms causes it and person become infected.The fungus increase the number into the body and increase the risk of disease .
Preventions from paracoccidioidomycosis:
Those people which lives in the outer areas like rural areas the fungus must present in the air and cause infection .So it is very difficult to prevent from the infection because it is present in air .The people who live in these areas not infected because they are resistant to this fungus .
But the people comes from outer areas caught it very firstly . They can not bear this infection. So, the fungus attacked him. The symptoms started of disease and the person became sick .
Sources of Para coccidioidomycosis
The exact transmission of this disease is not known by scientists .But those people which live in the rural areas sent their children to outdoor jobs .
Where this fungus caught accidently to them .By breathing it reach in to the body increase in number so the infection started .The exact time and season not known to the scientists .It is found in south central America . It is also found in Brazilian areas .It is also found in armadillo areas .
Number of patients recorded:
There were more than 15000 people which are recorded in 1930 .This number was very high in the brazil .All the people symptoms was same . They lived in the rural areas .In these areas the number of patients was about 80%. But this case was rare in the United States because the number of patients reported in these areas were about 5% only .
The death rate of the sick people was about 5% .
Life cycle of Para coccidioidomycosis
The life cycle of the coccidiosis is consists as following stages:
When a man worked in the field or in the soil the fungus is founded there .So they cause attached to the man and the symptoms started.
It is the first stage formed by the fungus. As man worked ,There are so many arthroconidia are distributed in the soil.So the pull to the man .Their size is about 3-5um. They formed so many cells along with mycelia .They increased in number and formed egg.It caused infection and the disease started.
First stage the arthroconidia are inhaled to the man by breath and by nasal cavity.
They entered the body.
After 24 hours they become larger and larger.They nourish on the blood cells and increase in number.
In the 48th hour the nuclear division started. The spore formation takes place. After 72 72houres the immature spherules are formed. The endospores formed on the spherules .
They make combinations with each other. The spherules and the endospores make combinations.
After the 96hours the endospores covered in the spherules .They stayed here for five days.
After the fifth day the spores are found in the spherule .The spherules release the endospores and burst.
After this tubular structures are formed and the shape is changed into mycelium .The mycelium are formed and found in the body disease cause infection.
Treatment of Para coccidioidomycosis
The jack had found that the some antifungal medications .These drugs infected the fungi and the symptoms included .The drugs are called itraconazole .
It is very infected .It is caused as 95% effective .But the Jake use it for 6 month and effected .
There are following treatments of the disease of Paracoccidioidomycosis.
- Lipo Amides were the first treatment.
- Itraconazole is first-line treatment.
- Antifungal treatment includes.
- Ketoconazole has toxicity and side effects.
- In serious cases the patients are treated with amphotericin B.
- Peptide vaccine.
Home remedies of Para coccidioidomycosis
- The care of this disease is not difficult but handling is most difficult .
- Always use a mask.
- Don not breathe in dirty air.
- Use clean and pure water.
- Always use healthy food
Possible Medications of Paracoccidioidomycosis
For the prevention of this disease we can use the following antifungal medicines:
It is also found in other forms such as injection and syrups etc.
- Amphotericin B