Prolactinoma – causes, symptoms, diagnosis, treatment

Table of Contents

Prolactinoma is a pituitary gland tumor, these are released hormones which are known as prolactin. This is a simple type of functional pituitary tumor. This tumor is not cancerous in the gland. They have some effects. They also decrease some sex hormones in women like estrogen. Also, decrease the hormone level in men like testosterone.

The breast is stimulated by the prolactin and the breast releases milk. They have major functions like moot regulation. The level of prolactin is high at the time of pregnancy and may remain high after the birth of the child. The level of prolactin becomes low or normal when breastfeeding is started.


They function properly for sexual refractory time. They broke down into two subsets based on scale.

  1. Macroprolactin: it may be more than 10 mm in diameter. It commonly occurs in males.
  2. Macroprolactin: the diameter of these is less than 10 are commonly occurring in the female. It is about 78.8% in females and more common than Macroprolactin.


Indication and side effects are not easily noticeable. However, the high concentration of prolactin in blood shows some side effects of Prolactinoma. It causes many problems in male and females. Prolactinoma indication and side effect in a woman.

Menstrual period regulation, Menstrual period deficiency, Pain during intercourse due to dryness of the vagina, Decrease in sex drive, Milk production unusually and Fertility problems. But if the size is increased then it also effects on other tissue and organ when it sizes increase following indication appear

  • Vision loss
  • Vision change
  • Headaches

 In Male

Prolactinoma also disturb male hormones and health so it shows following indication

  • Problem in maintaining an erection
  • Breast discharge can occur in males, but in females, it seems less common.
  • Decrease in sex drive
  • Abnormalities in the erect penis

If the tumor size increases then it affects other organ and tissue so it shows any indications such as Headaches, Vision Problem, and Stress on the optic nerves and Infertility. Some men and women also develop low bone mineral density due to the reduced levels of estrogen and testosterone that may occur with elevated prolactin; however, fractures and osteoporosis are uncommon.

Individuals with Prolactinoma have an increased chance of developing osteoporosis. Prolactinoma leads to too much prolactin throughout the body which results in lower estrogen and testosterone levels. It can lower bone mineral density in men and women alike. Reduced bone density raises the chance of osteoporosis, a condition that makes bones brittle and weak.


Most of the pituitary tumor develops by itself. The origins of pituitary tumors are still unexplained. This stress will increase the level of prolactin, so these isolated treatments perform. The tumor form by causes which is following

Medicine cause Prolactinoma

One problem or cause of Prolactinoma is miss use of medicine or overproduction of medicine. Depression (tricyclic and SSRI antidepressants). Birth control medicine. Serious mental health problems (dopamine antagonists such as Dispersal and haloperidol) Menopausal complications (estrogen). excessive use of medicine increases prolactin hormone in the blood.

In heredity problems cause Prolactinoma

Usually, Prolactinoma develops in person by chance without any association with a genetic condition. But in some cases, Prolactinoma develops due to mutation in genes. Genetically Prolactinoma is about 2.6% in the population. The genetic problem also plays a role in the formation of Prolactinoma. The heredity problem transfer of this disease occurs in a rare case, for example, the heredity disorder multiple endocrine neoplasia type 1 increases the chance of Prolactinoma.

Drugs cause Prolactinoma

Prolactin release by the pituitary gland and its effect on dopamine chemical which is released by the brain. Excess use of drugs causes reduced dopamine storage in the brain so it affects the pituitary to release high amounts of prolactin which cause Prolactinoma.

Drugs diagnosed for psychiatric and gastrointestinal defects may increase the level of prolactin to over the normal level. Many drugs that may cause minor amounts of prolactin involve estrogens and verapamil; a drug must always regard high blood pressure.

High level of prolactin cause Prolactinoma

In normal conditions prolactin releases in the perfect amount in male and females but in some conditions, it is disturbed due to during pregnancy and breastfeeding, prolactin levels normally rise. At other occasions, they may also rise slightly due to physical stress, such as a painful blood drain performing a meal, sexual intercourse nipple stimulation injury or epileptic seizures in the chest area.

Other cause of Prolactinoma

It is also caused by miss function of the thyroid gland. It is also caused by the high concentration of prolactin in the blood, also due to renal failure.

Clinical characteristics

The clinical characteristics of Prolactinoma vary primarily by gender, starting age, tumor size and PRL levels. Clinical symptoms in males include late puberty, gynecomastia, and galactorrhea, but due to the increased prevalence of macro adenomas, we have noted a more frequent occurrence of neuro-ophthalmological signs (visual impairment, headaches, etc.).

The high incidence of macro adenomas in males correlates with results in adults where this was related in part to postponed referral and/or onset of symptoms compared to females Irrespective of its trigger, Hyperprolactinemia interacts with secretary GnRH secretion and prevents LH and FSH secretion, allowing both sexes to become hypogonadism and childless.

Moreover, a prolactinoma’s mass can cause tensile impacts on parasellar systems and hypopituitarism. Many prolactinoma’s develop in women aged 20 to 34 but can occur in both sexes at any age. Kids are rarely affected by the condition. In children, Prolactinoma is rare and induces late development and growth that cause late maturity in kids.


The different method used in diagnosing the Prolactinoma which is following

Blood test

The first step in the analysis is to draw a sample of blood to measure the level of prolactin. The sample can be obtained at any period during the day and a normal level for women is below 25 ng/milliliters and in male is below 17ng/milliliters. Commonly one sample is sufficient to make the test. If the amount of prolactin is slightly high the test may need to be replicated because even the blood pressure and pain may affect the tests.

Doctors use the results of two tests to diagnose Prolactinoma. Your doctor will take a glance for other circumstances during the analysis that may increase concentrations of prolactin and may draw additional blood samples to test other levels of the hormone.

Imaging test

If your prolactin level is high and all other tests are acceptable, the next move is to search the pituitary gland with and without a contrast dye using a magnetic resonance imaging (MRI). The MRI scan can display if the pituitary has a tumor, its size and if the tumor has damaged the optic nerves or other pituitary surrounding areas.

When the prolactin levels are high the thyroid function is disturbed and told to other conditions known to increase prolactin secretion. The doctor advised (MRI) that a very large sensitive checkup for detecting pituitary tumors and knowing the size of the tumor progression assesses MRI scans.

The image of the pituitary gland is also scanned by CT (computerized tomography).The doctor destroys the surrounding tissue and assesses for test performance. On the other side, the population of any other pituitary hormone is also normal. The doctor request depends on the size of tumor with the calculating of the visual field

Treatment of Prolactinoma

The purpose of treatment is to restore the Prolactinoma release to normal, decrease the scale of tumor, incorrect normal of analysis. When there are big tumors, the total requirement of feasible such targets.

Fix any tumor-related problems such as menstrual issues, milky breast discharge, and low levels of testosterone, headaches, or vision problems. The treatment performs to improve the quality of life.


In general surgery or operation is fixing any tumor-related issues such as menstrual problems, milky breast discharge, low testosterone levels, headaches, or vision problems. The operation performs to deleting the tumor component must regard unless medical operation not is accepted or the even prolactin levels are not decreased, standard breeding and hypophyseal work restored and tumor level of scale reduced.

The tumor is almost always deleted by the nasal cavity. Occasionally will the neurologist obtain the tumor within an opening in the skull when the tumor is massive or could distribute for brain tissue surrounding. The results of the treatment are highly dependent on the tumor size and prolactin levels as well as the neurosurgeon’s ability and knowledge. The reduced possibility of serum prolactin normalization.

The serum is the blood part used to calculate the levels of prolactin. In certain in the best healthcare centers Eighty percent of patients with small tumors and serum prolactin less than 200 nanograms per milliliter, therapy adjusts prolactin concentration. Even a patient’s large tumor could not replace drug treatment or return prolactin concentration to perfect condition after surgery.

Although the results of the treatments are so based on the neurosurgeon’s knowledge and experience, a sufferer must ask the surgeon how many surgeries he or she has operated to delete pituitary tumors and how effective and complex they are compared to major medical centers.

 Radiation treatment

Usually, radiotherapy is used if there is no decrease in prolactin levels by surgical intervention and treatment. It is produced in small amounts above the sequence of five to six weeks or a single great amount, based on the size and place of the tumor. Only around 30 per cent of the time, radiation therapy is successful.

Treatment for fertility

If a female has a small Prolactinoma, after successful medical therapy she may typically conceptualize and get a healthy pregnancy. A female with Prolactinoma must talk with the doctor about her strategies to reproduce so that her pregnancy can be analyzed delicately, such as an MRI to analyze the cancer cell size and optical analysis to measure visual fields.

Usually, your doctor will suggest that you stop pulling bromocriptine or Cabergoline when a female is pregnant. While these treatments are secured for the fetus during early pregnancy, their protection has not yet been developed across the pregnancy.

In women without hypophysis, hypophyseal growth and production of prolactin during pregnancy increase. Women with tumors that emit prolactin may promote hypophysis and need to be carefully checked during gestation. Fewer than three percent of females with low prolactinoma suffer from tumor development side effects like pains or problems of sight.

 Natural treatment

The pituitary gland is one of the hormone project’s many glands-the signal source of the body that controls hormone release and connection throughout the body.

A pituitary Prolactinoma tumor may be handled with medication or with herbal Vitex agnus cestus. They function as inhibitors of dopamine and can decrease prolactin development and shorten the tumor. Vitex is also famous for maintaining hormone balance and controlling menstrual cycles.

Improve your health to hold the stress levels down. Avoid high-intensity exercises or movements which will exhaust you. Evicting clothes to render the chest uncomfortable. Eviting clothes and events that over-stimulate your nipples. Taking supplements of Vitamin B-6 and Vitamin E.

People with Prolactinoma need to get calcium and vitamin D, either through diet or vitamin products this medicine also saves from bone problems.


It is believed that a whole compound found in fruits and vegetables, especially dark, leafy greens, would improve the wellbeing of anyone. Complete grains should also be in the diet; legumes, particularly soybeans; legumes; and water fish. Further than this, some foods tend to be especially beneficial in lowering prolactin levels.


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