Kikuchi Disease : causes, symptoms, diagnosis, treatment

Kikuchi Disease A disease commonly caused by fever and a crucial stage of lymphadenopathy is known as Kikuchi-Fujimoto and the other name for this disease is Kikuchi’s necrotizing of histolytic.

This disease was nominated by Dr. Masahiro Kikuchi in the very first years of the 1970s in Japan and then explained by Y. Fujimoto in detail. This is not a very serious and severe condition of nodes of lymph.

  Its basic and common symptoms are mild attacks of fever, sweat over the neck, lymph nodes, and puffing. There are also some other symptoms that are not more important as bad throat, loss of weight, and vomiting.

But the actual cause and reason are unknown still, so there are some recommended. The duration of this disease is round about four to five months in which this disease is automatically resolved while this may prolong to one year if it is not treated properly. As we know that the proper treatment of this disease is available now.

Affected Populations

Kikuchi’s disease, first reported in Japan in 1972, has been reported in less than 50 cases in the medical literature. It mainly affects young adults, but can occur at any age.

Preliminary reports indicate that Kikuchi affects women more often than men in a 4: 1 ratio. Recent reports suggest that the proportion is not that high. Kikuchi disease is more frequent in Southeast Asia.

Kikuchi’s disease may be more common than previously identified because swollen glands are common and often overlooked. As a result, coupled with the self-limiting nature of the disorder, some medical experts have speculated that Kikuchi’s disease is far more common than previously thought.

Because tissue biopsies in the affected lymph nodes can only detect the disorder, many unstable individuals and physicians may ignore it.

Related Disorders

After the diagnosis of various patients, the symptoms could be observed in the form of the result in the form of disorders which seem very similar to those of Kikuchi’s disease.

In some patients pursuing conditions are associated with Kikuchi disease. They are not necessary for discriminatory assessment:

Pancytopenia– in this situation, platelets, white and red blood cells are decreased during circulation.

Hypertrophy – an abnormal expansion of the spleen.

Still’s a disease – too called joint rheumatoid arthritis or rheumatoid arthritis, is a type of arthritis that normally, but not specifically, affects large joints in children.

Symptoms of Kikuchi Disease

In the very early stage of Kikuchi disease, the following symptoms appeared in the form of swallowing of nodes in the neck that gradually increased and becomes a sign of critical situation in the patient.

The main symptom is usually swollen neck disease in lymph nodes, which tend to arise suddenly. Many Other symptoms may include. Lymph nodes are the malignant symptom in the disease of Kikuchi.

 Another intense sign and symbol of this disease is commonly lymph node those were increased in size around the neck, which tend to grow quickly. Another symbol may consider: Abdominal pain.

Causes of Kikuchi Disease

The basic and common reason and cause of the Kikuchi illness is unknown. But the doctors have suggested two possible explanations for this disease and illness.

A few doctors had the firm idea that this may cause and indicates a severe virus or another agent for critical infection.

 The described idea was supported to some wireless features include adherence to infection with symptoms such as frequent disease and spontaneous resolution of this case with or without specific treatment (including self is gone).

 Others think it could be an automated term. According to this theory, when many factors stimulate the immune response than Kikuchi disease occurs.


It is not thought that Kikuchi disease is inherited. Most happening in people who do not have a family situation. Recently, a case study was published in the literature of Kikuchi disease, which increased prognosis of genetic factors or perhaps genetic background.

Diagnosis of Kikuchi Disease

This is diagnosing by a lymph node excise biopsy. This disease is a self-restricting disease with indicate that lead to Hodgkin’s lymphoma, which can lead to misdiagnosis in some patients.

 And can help differentiate systemic lupus erythematosus.  The lymph node biopsy test of the disease confirms the diagnosis.

Treatment of Kikuchi Disease

Kikuchi disease usually understands within one to four months with or without proceeding. While medical discussion is present to release from associated disease. e.g., to reduce lymph node tenderness and fever no steroidal anti-inflammatory drugs can be used. In severe cases, the use of steroid hormone is suggested.

 Hydro-oxychloride-quine (an immunosuppressant drug) has also been used successfully, either alone or in combination with other treatments.

Because some cases of SLE or lupus have been reported many periods later recovery from Kikuchi disease, numerous medical examinations suggest that long run follow to examine the symptoms of SLE.

Prognosis of Kikuchi Disease

In general, the longest approach (diagnosis) in Kikuchi is so poor. Nodes of Lymph typically turn into normal form in the duration of 2 to 5 months. However, this can take more and more time.

Approximately 2 to 5individual can relapse into this disease.SLE is a very severe autoimmune disease which can influence on the both sides of kidneys, joints and in the whole skin.

 Their symbols vary from side to side even though near about whole persons with SLE have swelling and joints pain. A little produce pertaining to arthritis. Another sign involves chest pain, ill feeling and mouth sores.


Peripheral pathology is an infrequent complication of KFD.The symbols in this disturbance are either related.

Lymphoma brow was cancer that affects the lymphatic system to other parts of the body as well as lymph nodes. Kidneys, sex glands, jaw, bone marrow, or lymph nodes may also be tumors with the central nervous system.

 Lymphomas can brow is infectious. This disorder is often found in children living in East Africa, and it is connected to Epstein Barr virus.

Hodgkin’s lymphatic disease is a form of cancer, including tumor lymph nodes. Red Stemberg specialist treatment is called pathological cells show the presence of a confirmed diagnosis of Hodgkin’s disease.

Hodgkin’s did not know the real cause of the disease. Lymphoma malignant explains tumor malignant tissue is cancer. The lymph system is a type of white blood cell (lymphocyte) rotation.

 while white blood cell composition may vary with the type of Lymphoma, but the effects are usually the same. After the appearance of lymph is common attacks of fever, weakness, and loss of weight. When joining the mass of lymphoid tissue, may also enhance the spleen and liver.

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